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Assessment and AI-Based Prediction of Complications in Reduction Mammoplasty: A Combined Statistical and Fuzzy Inference Approach in a 10-Year Cohort from Tehran Hospitals (2013-2023).
[INTRODUCTION] Gigantomastia causes physical, psychological, and dermatological issues, often with ptosis; reduction mammoplasty effectively relieves symptoms but carries minor (self-limiting or medically managed) and major (surgically requ…
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Cosmetic outcomes of oncoplastic surgeries in breast cancer patients: an eleven-year experience from two tertiary referral centers.
[PURPOSE] Oncoplastic surgery (OPS) is an essential component of breast cancer treatment, aiming to achieve optimal aesthetic outcomes while ensuring oncological safety. However, evidence comparing the cosmetic outcomes of various OPS techn…
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Effect of Topical Timolol on Healing of Immature Breast Scars After Mammoplasty: A Randomized Controlled Trial With Blinded Assessors and Patients.
[INTRODUCTION] Wound healing is a complex process encompassing four main stages: hemostasis, inflammation, cell proliferation, maturation, and differentiation. Timolol (TM) may influence these stages, particularly re-epithelialization. This…
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Introducing an oncoplastic approach for centrally located breast cancer patients.
[INTRODUCTION] Central breast cancers pose a unique challenge to oncoplastic surgeons, given their proximity to the nipple-areola complex and the impact on cosmetic outcomes. This study aims to present a comprehensive algorithm designed to …
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Innovative technique for managing extreme relapsing bilateral pseudoangiomatous stromal hyperplasia (PASH) in a young woman: A case report highlighting a novel intervention in reconstruction.
[INTRODUCTION] Pseudoangiomatous stromal hyperplasia (PASH) is a rare breast stromal lesion that typically manifests clinically as a palpable unilateral, painless lump that is freely movable and has a rubbery or firm consistency. The diagno…
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Synthesis and characterization of a silk fibroin/placenta matrix hydrogel for breast reconstruction.
Reconstructive surgery is a complex and demanding interdisciplinary field. One of the major challenges is the production of sizeable, implantable, inexpensive bioprostheses such as breast implants. In this study, porous hybrid hydrogels wer…
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A methylation signature at the CpG island promoter of estrogen receptor beta (ER-β) in breasts of women may be an early footmark of lack of breastfeeding and nulliparity.
Although little is known regarding the mechanisms behind the onset of breast cancer (BC) through reproductive risk factors, new researches have highlighted some early tumor-related methylation footmarks in the breast tissue of apparently cl…
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Early Parity Epigenetic Footprint of FOXA1 Gene Body in Normal Breast Tissue of Iranian Women.
[BACKGROUND] Young age at first full-term pregnancy (FFTP) is an important factor in breast cancer risk reduction. It is postulated that this protective effect is the result of stable molecular signatures imprinted by physiological process …
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Methylation of progesterone receptor isoform A promoter in normal breast tissue: An epigenetic link between early age at menarche and risk of breast cancer?
Emerging evidence indicates that some altered patterns of methylation that occur in breast tumors may also be found in breast tissue of healthy women in relation to the breast cancer (BC) risk factors. Progesterone receptor (PR) isoform α i…
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Epigenetic Changes of the ESR1 Gene in Breast Tissue of Healthy Women: A Missing Link with Breast Cancer Risk Factors?
[BACKGROUND] Reproductive history and obesity are among the well-recognized risk factors in the development of breast cancer, which are partially mediated by the increased exposure of breast tissues to estrogens. However, only a few studies…