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Early prediction of adult lymphoma-associated haemophagocytic lymphohistiocytosis using an interpretable machine learning model.
Lymphoma-associated haemophagocytic lymphohistiocytosis (LA-HLH) is associated with a high mortality rate, making early diagnosis and appropriate treatment critical for improving patient outcomes. In this study, we enrolled 126 patients dia…
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Helicobacter pylori-induced aberrant methylation of ID4 mediated by DNMT3B drives gastric cancer progression via DEC1-SHH signaling pathway.
Helicobacter pylori (H. pylori) infection mediates activation of oncogenes and inhibition of tumor suppressor genes through aberrant DNA methylation, which is the predominant risk factor for gastric tumorigenesis. Here, by integrating trans…
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MTF1 attenuates ferroptosis and cuproptosis synergistic potentiation in gastric cancer.
The recent discovery of cell death mediated by metal ions has aroused significant interest in harnessing this novel mechanism of cell death for cancer therapy. As the two identified metal ion-based regulated cell death forms, ferroptosis an…