논문 목록
3건-
Neuromuscular dysfunction, independent of gait dysfunction, modulates trabecular bone homeostasis in mice.
[OBJECTIVES] To clarify the effects of neuromuscular dysfunction on hindlimb loading, muscle atrophy, and bone homeostasis. [METHODS] We quantified changes to hindlimb loading, muscle atrophy, and bone morphology following either Botulinum…
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Botulinum toxin A-induced muscle paralysis stimulates Hdac4 and differential miRNA expression.
At sufficient dose, intramuscular injection of Botulinum toxin A causes muscle wasting that is physiologically consistent with surgical denervation and other types of neuromuscular dysfunction. The aim of this study was to clarify early mol…
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Muscle paralysis induces bone marrow inflammation and predisposition to formation of giant osteoclasts.
Transient muscle paralysis engendered by a single injection of botulinum toxin A (BTxA) rapidly induces profound focal bone resorption within the medullary cavity of adjacent bones. While initially conceived as a model of mechanical disuse,…