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Gut mucin fucosylation dictates the entry of botulinum toxin complexes.
Botulinum toxins (BoNTs) are the most potent known bacterial toxins. The BoNT complex from B-Okra (large progenitor toxin complex (L-PTC)/B, hyper-oral-toxic) exerts at least 80-fold higher oral toxicity in mice compared with that from ser…
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Gut mucin fucosylation dictates the entry of botulinum toxin complexes.
Botulinum toxins (BoNTs) produced by Clostridium botulinum are the most potent known bacterial toxins. The BoNT complex from serotype B-Okra (LPTC/B) exerts at least 80-fold higher oral toxicity in mice compared with that from serotype A1 (…