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Silencing myeloid cell leukemia-1 improves apoptotic and ferroptotic responses in melanoma.
[BACKGROUND] Melanoma is a highly malignant skin cancer characterized by strong metastatic and invasive capabilities. Integrative transcriptomic profiling offers a systematic route to uncover tumor-specific regulatory hubs that could expose…
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Quantitative Top-Down Proteomics Reveals Significant Differences in Histone Proteoforms Between Metastatic and Nonmetastatic Colorectal Cancer Cells.
Colorectal cancer (CRC) development is closely associated with the accumulation of both genetic and epigenetic alterations. Many efforts have been made to investigate the role of epigenetic modifications in CRC metastasis. In this work, we …
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Upregulation of TTYH3 by lncRNA LUCAT1 through interacting with ALYREF facilitates the metastasis in non-small cell lung cancer.
Metastasis is the predominant culprit of cancer-associated mortality in non-small cell lung cancer (NSCLC). Tweety homolog 3 (TTYH3) reportedly functions vitally in the development of diverse cancers, including NSCLC; nevertheless, its role…