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6건-
Lipid-Engineered Small-Sized Metal-Organic Frameworks for Targeted Delivery of Anlotinib in Lung Cancer Treatment.
[PURPOSE] In this study, we report the design and evaluation of Anlo@MOF-Lipo (AML), a liposome coated, small sized MIL-101(Fe) metal-organic framework (MOF) for targeted delivery of the multi target tyrosine kinase inhibitor anlotinib in l…
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Unraveling the Dynamic Trajectories and Predictive Determinants of Fear of Cancer Recurrence in Breast Cancer Survivors: A Prospective Cohort Study.
[BACKGROUND] Fear of cancer recurrence (FCR) is a dynamic phenomenon linked to negative outcomes among breast cancer survivors. Longitudinal studies on its causal links are limited. The aim of the study is to chart FCR trajectories in breas…
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The 41BB-agonist potentiates the therapeutic efficacy of a combined irreversible electroporation ablation treatment of lung cancer by promoting unexpected CD8CD103 cDC1 and tissue-resident memory T cell responses.
Irreversible electroporation (IRE) is a relatively new, non-thermal ablation technology for cancer treatment that requires further investigation to optimize its therapeutic efficacy. To improve IRE-ablation, we developed an IRE+Combo-treatm…
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The effectiveness of anti-PD-L1 treatment and the underlying regulatory mechanism in ovarian clear cell carcinoma.
Ovarian clear cell carcinoma (OCCC) is typically associated with a poor prognosis. However, recent clinical trials have demonstrated that OCCC exhibits a nice response rate to immunotherapy. To identify whether anti-PD-L1 treatment was effe…
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Jianpi Huayu decoction enhances the antitumor effect of doxorubicin via piezo1-mediated autophagy in hepatocellular carcinoma.
[BACKGROUND] Hepatocellular carcinoma (HCC) carries a poor prognosis, especially in advanced stages. Although Piezo1, a mechanosensitive ion channel, is linked to HCC progression, its underlying mechanisms and therapeutic potential remain p…
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Investigation of the relationship between COVID-19 and pancreatic cancer using bioinformatics and systems biology approaches.
[BACKGROUND] The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, poses a huge threat to human health. Pancreatic cancer (PC) is a malignant tumor with high mort…