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Long-term efficacy with deep brain stimulation of the globus pallidus internus in cervical dystonia: a retrospective monocentric study.
[BACKGROUND] Cervical dystonia (CD) is characterized by involuntary contractions of the cervical muscles. Data on long-term effectiveness of deep brain stimulation (DBS) are rare. The aim of this study was to evaluate the longitudinal ten y…
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Managing Essential Tremor.
Essential tremor is one of the most common tremor syndromes. According to the recent tremor classification, tremor as a symptom is defined as an involuntary, rhythmic, oscillatory movement of a body part and is classified along two axes: ax…
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Urinary symptoms, quality of life, and patient satisfaction in genetic and sporadic hereditary spastic paraplegia.
[BACKGROUND] Urinary involvement is common in hereditary spastic paraplegias (HSPs), but has rarely been assessed systematically. [METHODS] We characterized urinary complaints in 71 German HSP patients (mean age 55.4 ± 13.9 years; mean dis…
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MDS evidence-based review of treatments for essential tremor.
[BACKGROUND] Essential tremor is one of the most prevalent movement disorders. Many treatments for essential tremor have been reported in clinical practice, but it is uncertain which options have the most robust evidence. The International …
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Deep Brain Stimulation in Movement Disorders: From Experimental Surgery to Evidence-Based Therapy.
Deep brain stimulation (DBS) of 3 different targets is the most important therapeutic innovation of the past 30 years for patients with fluctuating Parkinson's disease (PD), disabling dystonia, tremors, and refractory Gilles de la Tourette …
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Pharmacokinetics and pharmacodynamics of incobotulinumtoxinA influencing the clinical efficacy in post-stroke spasticity.
[INTRODUCTION] Post-stroke spasticity is a disabling neurological condition and may have a significant impact on quality of life. Ability to carry out activities of daily living is often compromised and painful contractures in the affected …
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Pathophysiological Concepts and Treatment of Camptocormia.
Camptocormia is a disabling pathological, non-fixed, forward bending of the trunk. The clinical definition using only the bending angle is insufficient; it should include the subjectively perceived inability to stand upright, occurrence of …