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Multicenter, Randomized Split-Face Trial of a Crosslinked Hyaluronic Acid Filler With Lidocaine for Nasolabial Fold Correction.
[BACKGROUND] Nasolabial folds (NLFs) are common age-related facial lines, often treated with dermal fillers. Princess® FILLER Lidocaine (PFL; now saypha® filler Lidocaine) and Juvéderm® Ultra XC (JUXC) are both hyaluronic acid-based fillers…
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RelabotulinumtoxinA, a Ready-to-Use Formulation Neuromodulator Manufactured with PEARL™ Technology to Maintain High Biological and Specific Activity.
Most botulinum toxin A (BoNT-A) products for esthetic use require reconstitution before administration. Ready-to-use relabotulinumtoxinA is a liquid manufactured using Precipitation-free Extraction and Activity-preserving, Refined Liquid (P…
- Gender transition during a clinical trial.
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Laser-Assisted Drug Delivery in the Treatment of Scars, Rhytids, and Melasma: A Comprehensive Review of the Literature.
Although broad reviews on laser-assisted drug delivery (LADD) have been published in the past, an updated focused examination of its utility in the context of common, treatment-resistant, dermatologic conditions has not been published. This…
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Decades of beauty: Achieving aesthetic goals throughout the lifespan.
[BACKGROUND] Several elements, including age, influence judgments of beauty and attractiveness. Aging is affected by intrinsic factors (e.g., genetics, race/ethnicity, anatomical variations) and extrinsic factors (e.g., lifestyle, environme…
- Characterizing Ocular Adverse Events After Facial Dermal Filler Injection-Reviewing the MAUDE Database.
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DaxibotulinumtoxinA for Injection for the Treatment of Glabellar Lines: Efficacy Results From SAKURA 3, a Large, Open-Label, Phase 3 Safety Study.
[BACKGROUND] DaxibotulinumtoxinA for Injection (DAXI) is botulinum toxin Type A formulated with a novel peptide excipient. Two pivotal, single-treatment, placebo-controlled trials demonstrated efficacy and safety for moderate or severe glab…
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Prior Botulinum Toxin Treatment Does Not Impact Efficacy or Safety in Clinical Trials: Analysis of DaxibotulinumtoxinA for Injection in the SAKURA Program.
[BACKGROUND] Pivotal studies of approved botulinum toxin type A (BoNTA) formulations for treatment of glabellar lines have mostly included treatment-naive participants, and the impact of prior BoNTA treatment on efficacy and safety is not w…
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The Second of Two One-Year, Multicenter, Open-Label, Repeat-Dose, Phase II Safety Studies of PrabotulinumtoxinA for the Treatment of Moderate to Severe Glabellar Lines in Adult Patients.
[BACKGROUND] PrabotulinumtoxinA is a 900-kDa botulinum toxin type A produced by Clostridium botulinum. [OBJECTIVES] The authors sought to investigate the safety of prabotulinumtoxinA for treatment of glabellar lines. [METHODS] This was a …
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Nitroglycerin, or Not, When Treating Impending Filler Necrosis.
[BACKGROUND] Dermal necrosis is a rare yet serious risk associated with cosmetic filler injections, and although current consensus recommends the use of hyaluronidase injections in cases of hyaluronic acid filler, the efficacy of topical ni…
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Delayed Inflammatory Reactions to Hyaluronic Acid Fillers: A Literature Review and Proposed Treatment Algorithm.
[BACKGROUND AND OBJECTIVES] There is a wide diversity of opinions regarding the management of delayed inflammatory reactions (DIRs) secondary to hyaluronic acid (HA)-based fillers. The plethora of approaches has led the authors to conduct a…
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Maximizing Panfacial Aesthetic Outcomes: Findings and Recommendations From the HARMONY Study.
[BACKGROUND] Aesthetic medicine has evolved from targeting individual treatment areas to a global approach of panfacial rejuvenation. HARMONY was the first clinical study to systematically demonstrate positive physical and psychosocial impa…
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Treatment of Atrophic Facial Acne Scars With Microneedling Followed by Polymethylmethacrylate-Collagen Gel Dermal Filler.
[BACKGROUND] Microneedling and soft-tissue filler injections have been used independently to improve acne scarring. The effectiveness of a combined approach using microneedling followed by polymethylmethacrylate (PMMA)-collagen gel has not …
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A Combination Approach to Perioral Rejuvenation.
Fine lines and wrinkles, loss of volume, texture changes, and solar lentigines around the mouth are the result of both extrinsic and intrinsic factors, and are common concerns seen in cosmetic practice. Perioral rejuvenation can be addresse…
- Prospective Randomized Split-Face Comparative Study Between Topical Botulinum Toxin A Surface Application and Local Injection for Crow's Feet.
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A Comprehensive Approach to Multimodal Facial Aesthetic Treatment: Injection Techniques and Treatment Characteristics From the HARMONY Study.
[BACKGROUND] The HARMONY study is the first clinical trial to assess the impact of a global approach to facial rejuvenation with several minimally invasive modalities, using patient-reported outcome measures. [OBJECTIVE] Provide details of…
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Treatment of Hyaluronic Acid Filler-Induced Impending Necrosis With Hyaluronidase: Consensus Recommendations.
Injection-induced necrosis is a rare but dreaded consequence of soft tissue augmentation with filler agents. It usually occurs as a result of injection of filler directly into an artery, but can also result from compression or injury. We pr…
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An interrater and intrarater reliability study of 3 photographic scales for the classification of perioral aesthetic features.
[BACKGROUND] Validated aesthetic rating scales for the perioral area provide objective evaluations for clinical trials and practice. [OBJECTIVE] To confirm the reliability of 3 scales for evaluating dermal filler and neurotoxin treatments …
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Are we too cavalier about antiviral prophylaxis?
Herpes simplex virus (HSV) prophylaxis may be underutilized in cosmetic surgery at a time when cosmetic procedures are increasing. Our goal is to review the data regarding HSV prophylaxis in order to remind cosmetic surgeons when to conside…
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Nitroglycerin: a review of its use in the treatment of vascular occlusion after soft tissue augmentation.
[BACKGROUND] Skin necrosis after soft tissue augmentation with dermal fillers is a rare but potentially severe complication. Nitroglycerin paste may be an important treatment option for dermal and epidermal ischemia in cosmetic surgery. [O…
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Etiology, prevention, and treatment of dermal filler complications.
The availability of dermal fillers for multiple cosmetic indications has led to a dramatic increase in their application. Although fillers are generally regarded as safe tools for soft tissue augmentation, complications can occur. Therefore…
- Dermal fillers in patients on anticoagulants.
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Understanding, avoiding, and managing dermal filler complications.
BACKGROUND Dermal fillers are increasingly being utilized for multiple cosmetic dermatology indications. The appeal of these products can be partly attributed to their strong safety profiles. Nevertheless, complications can sometimes occur.…
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Soft tissue augmentation.
Recent additions to the soft tissue augmentation armamentarium have greatly increased the dermatologic surgeon's choices in optimizing facial contouring and the treatment of acne scars. In this article, we review the science of fillers and …