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Skeletal muscle-derived IL-33 mediates muscle-to-bone crosstalk and regulates bone metabolism via CD8 T cell-secreted CCL5.
[BACKGROUND] Skeletal muscle-to-bone crosstalk may play critical roles in the association between muscle atrophy and bone loss. Here, we report a myokine, IL-33, which may mediate muscle-to-bone crosstalk. [METHODS] A cohort study was cond…
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Role of IL-16 in age-related skeletal muscle atrophy: an integrated study.
[BACKGROUND] In this study, we aim to explore the roles of IL-16 in sarcopenia based on older orthopedic patients and animal research. [METHODS] This clinical research in this study was an observational investigation and included all the o…