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Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on Hearing Preservation Outcomes in Patients With Sporadic Vestibular Schwannoma: Update.
[BACKGROUND] Given the increasing prevalence and shifting disease demographic of vestibular schwannoma toward smaller tumors in people with less advanced symptoms, increasing emphasis has been placed on functional hearing preservation. [OB…
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Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on Surgical Resection for the Treatment of Patients With Vestibular Schwannomas: Update.
[BACKGROUND] Surgical intervention remains an important option in the management of vestibular schwannoma (VSs). Development of a systematic approach to choose the most appropriate route for this intervention, based on existing published ev…
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Nonconventional Imaging Modalities for Vestibular Schwannoma Prognosis: A Scoping Review.
[OBJECTIVE] To explore the existing evidence on novel imaging modalities that may aid in prognostication of vestibular schwannoma (VS) clinical outcomes across various management approaches. [STUDY DESIGN] Scoping review. [SETTING] Not ap…
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Leveling the Playing Field in Vestibular Schwannoma Outcome Reporting: A Survey of Variance and Bias in Published Research.
[OBJECTIVE] To survey critical areas of variation in published research methodology with a primary aim of highlighting fundamental aspects that contribute to ongoing controversy surrounding optimal management of patients with sporadic vesti…
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Defining clinically significant tumor size in sporadic vestibular schwannoma to inform timing of radiosurgery during wait-and-scan management: further evidence supporting size threshold surveillance.
[OBJECTIVE] Wait-and-scan surveillance is now commonly employed for initial management of small- and medium-sized vestibular schwannomas. Although small differences in tumor size are unlikely to impact outcomes significantly, treatment with…
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Sex-based Differences in Quality of Life for Sporadic Vestibular Schwannoma Patients Managed With Observation, Microsurgery, or Radiation.
[OBJECTIVE] Quality of life (QOL) is an important consideration in vestibular schwannoma (VS) patients when assessing management options. Understanding sex-based differences in QOL may facilitate patient counseling. [STUDY DESIGN] Prospect…
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Salvage Microsurgery After Failed Bevacizumab Treatment for NF2-Related Schwannomatosis Vestibular Schwannoma: A Multicentric Retrospective Study.
[BACKGROUND AND OBJECTIVES] Surgery in NF2-related schwannomatosis (NF2-SWN) vestibular schwannoma (VS) carries a higher risk of facial nerve damage, hearing loss, and partial resection, than in sporadic cases. Radiosurgery is also associat…
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Cochlear Implantation With Sporadic Inner Ear Schwannomas: Outcomes in 106 Patients From an International Multi-Institutional Study.
[OBJECTIVE] To evaluate cochlear implant speech perception among patients with sporadic inner ear schwannoma who underwent ipsilateral implantation. [STUDY DESIGN] Retrospective multi-institutional cohort study. [SETTING] Eleven tertiary …
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Management of vestibular schwannoma in the elderly.
The elderly population has been expanding and is expected to continue to do so in the future. This, together with advances in work-up for SNHL, led to an increase in the incidence of VS, with smaller tumor sizes and older ages at the time o…
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Optimal Timing of Primary Radiosurgical Treatment of Growing Vestibular Schwannoma: Insights From Salvage Microsurgery Outcomes.
[OBJECTIVE] Limited evidence guides the optimal timing of treatment after the detection of tumor growth during the observation of sporadic vestibular schwannoma (VS). The current work aimed to inform the timing of radiosurgical intervention…
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Prospective Symptom Changes in Sporadic Vestibular Schwannoma: A Comparison of Observation, Microsurgery, and Radiosurgery.
[OBJECTIVE] To compare differences in sporadic vestibular schwannoma (VS)-associated patient-reported symptom scores among patients receiving observation, microsurgery, or radiosurgery. [STUDY DESIGN] Prospective longitudinal survey. [SET…
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Impact of Vestibular Schwannoma Management on Cochlear Implant Programming and Outcomes.
[OBJECTIVES] To compare electrical stimulation and speech perception in vestibular schwannoma (VS) patients across treatment modalities and standard cochlear implant (CI) patients. [STUDY DESIGN] Retrospective review. [SETTING] Tertiary a…
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Salvage Microsurgery Following Failed Primary Radiosurgery in Sporadic Vestibular Schwannoma.
[IMPORTANCE] Management of sporadic vestibular schwannoma with radiosurgery is becoming increasingly common globally; however, limited data currently characterize patient outcomes in the setting of microsurgical salvage for radiosurgical fa…
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Repeat Radiosurgery for Sporadic Vestibular Schwannoma After Primary Radiosurgical Failure: An International Multi-institutional Investigation.
[OBJECTIVE] To describe outcomes of patients with sporadic vestibular schwannoma (VS) who underwent repeat stereotactic radiosurgery (SRS) after primary SRS failure. [STUDY DESIGN] Multi-institutional historical cohort study. [SETTING] Fi…
- Assessing Facial Nerve Function After Salvage Microsurgery for Vestibular Schwannoma-Reply.
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Long-Term Prospective Quality-of-Life Outcomes in 445 Patients with Sporadic Vestibular Schwannoma.
[OBJECTIVE] To evaluate the long-term changes in sporadic vestibular schwannoma (VS) disease-specific quality-of-life (QOL) outcomes. [STUDY DESIGN] Prospective longitudinal study using the Penn Acoustic Neuroma Quality of Life (PANQOL) Sc…
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Comparing Cochlear Implant Outcomes in 100 Patients With Sporadic Vestibular Schwannoma Managed With Observation, Radiosurgery, or Microsurgery: A Multi-Institutional Review.
[OBJECTIVE] To compare cochlear implant (CI) speech perception outcomes in patients with sporadic vestibular schwannoma (VS) managed with observation, radiosurgery, or microsurgery. [STUDY DESIGN] Retrospective review. [SETTING] Eleven te…
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Comparing Patient Satisfaction After Upfront Treatment Versus Wait-and-Scan for Small Sporadic Vestibular Schwannoma.
[OBJECTIVE] Management of small vestibular schwannoma (VS) remains controversial, as patients are typically candidates for all three management options including microsurgery, stereotactic radiosurgery, or wait-and-scan. This study compares…
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Salvage radiosurgery following subtotal resection of vestibular schwannomas: does timing influence tumor control?
[OBJECTIVE] The goal of microsurgical resection of vestibular schwannoma (VS) is gross-total resection (GTR) to provide oncological cure. However, a popular strategy is to halt the resection if the surgical team feels the risk of cranial ne…
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Quality of Life in Sporadic Vestibular Schwannoma.
The focus of management in sporadic vestibular schwannoma has dramatically evolved over the last 100 years. The centrality of quality of life (QoL) is being underscored by an ongoing epidemiologic shift toward an older patient demographic t…
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Cochlear Implant Outcomes between Patients with Sporadic and Neurofibromatosis Type 2-Associated Vestibular Schwannoma.
[OBJECTIVE] Compare cochlear implant (CI) performance between patients with ipsilateral sporadic vestibular schwannoma (VS) and NF2-related schwannomatosis (NF2). Compare CI performance according to VS management modality. [STUDY DESIGN] H…
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Defining clinically significant tumor size in vestibular schwannoma to inform timing of microsurgery during wait-and-scan management: moving beyond minimum detectable growth.
[OBJECTIVE] Detection of vestibular schwannoma (VS) growth during observation leads to definitive treatment at most centers globally. Although ≥ 2 mm represents an established benchmark of tumor growth on serial MRI studies, 2 mm of linear …
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Long-term surgical outcomes of intracranial epidermoid tumors: impact of extent of resection on recurrence and functional outcomes in 63 patients.
[OBJECTIVE] The authors' objective was to reevaluate the role of microsurgery for epidermoid tumors by examining the associations between extent of resection (EOR), tumor control, and clinical outcomes. [METHODS] This was a retrospective s…
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Hearing Preservation in Observed Sporadic Vestibular Schwannoma: A Systematic Review.
[OBJECTIVE] To characterize the natural history of hearing loss for patients presenting with serviceable hearing (SH) who undergo a wait-and-scan approach for sporadic vestibular schwannoma (VS) using aggregate time-to-event survival analys…
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Hearing Preservation Microsurgery in Vestibular Schwannomas: Worth Attempting in "Larger" Tumors?
[OBJECTIVES/HYPOTHESIS] To review hearing preservation after microsurgical resection of sporadic vestibular schwannomas according to tumor size. [STUDY DESIGN] Retrospective cohort. [METHODS] Baseline, intraoperative, and postoperative pa…
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Predicting Extent of Microsurgical Resection of Sporadic Vestibular Schwannoma.
[OBJECTIVE] Develop a predictive model for incomplete microsurgical resection of sporadic vestibular schwannoma (VS). [STUDY DESIGN] Historical cohort. [SETTING] Tertiary referral center. [PATIENTS] Patients with sporadic VS. [INTERVENT…
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Fluorescein-Assisted Microsurgical Resection of Vestibular Schwannoma: A Prospective Feasibility Study.
[OBJECTIVE] To evaluate the optimal dose and timing of administration of sodium fluorescein (SF) for selective fluorescence of sporadic vestibular schwannoma (VS) during microsurgery with the YELLOW 560-nm microscope filter (YE560) and to c…
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Prospective Study of Disease-Specific Quality-of-Life in Sporadic Vestibular Schwannoma Comparing Observation, Radiosurgery, and Microsurgery.
[BACKGROUND] Previous cross-sectional studies analyzing quality of life (QOL) outcomes in patients with sporadic vestibular schwannoma (VS) have shown surprisingly little difference among treatment modalities. To date, there is limited pros…
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Evolution in Management Trends of Sporadic Vestibular Schwannoma in the United States Over the Last Half-century.
[OBJECTIVE] Limited data currently characterize management trends of sporadic vestibular schwannoma (VS) in the United States over recent decades. Serving as the primary patient support organization in the United States, the Acoustic Neurom…
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Disease-Specific Quality of Life in Vestibular Schwannoma: A National Cross-sectional Study Comparing Microsurgery, Radiosurgery, and Observation.
[OBJECTIVE] To examine the impact of treatment on disease-specific health-related quality of life (HRQOL) among patients with sporadic vestibular schwannoma (VS). [STUDY DESIGN] National cross-sectional study. [SETTING] Tertiary referral …