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Histopathological Scoring Improves the Correlation Between Capsular Contracture Diagnosis and Patient-Reported Outcomes.
[BACKGROUND] The Baker classification is used to grade capsular contracture after breast-implant surgery; yet, its correlation with patient-reported outcomes is poor. [OBJECTIVES] To determine whether histopathological verification of caps…
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Breast Implant Rupture Is Strongly Associated with Capsular Contracture: An Intrapatient Study.
[BACKGROUND] Capsular contracture is a common complication following breast augmentation and reconstruction with implants. Implant rupture is suspected to cause capsular contracture, but the evidence remains limited. [METHODS] This intrapa…
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Quantifying Silicone Leakage In Vivo: Validation of a Reproducible Histological Method for Breast Implant Surveillance.
[BACKGROUND] Silicone leakage from breast implants may contribute to fibrosis leading to capsular contracture, yet no standardized method exists to quantify silicone leakage reliably. [OBJECTIVES] To validate a histological method for quan…
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Silicone Leakage From Breast Implants and Its Association With Capsular Contracture in 657 Patients.
[BACKGROUND] Capsular contracture is a common complication following breast reconstruction and augmentation, but there is limited evidence for the association between silicone leaking from the implant and capsular contracture. [OBJECTIVES]…
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Breast implant microbiome profile correlates with foreign body response severity.
Biomedical implants significantly enhance quality of life for millions of individuals worldwide. However, maintaining long-term implant function remains challenging, and it is often due to a severe foreign body response, characterized by fi…
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Long-Term Volume Retention of Breast Augmentation with Fat Grafting Depends on Weight Changes: A 3-Year Prospective Magnetic Resonance Imaging Study.
[BACKGROUND] Fat grafting is increasingly used for breast augmentation. However, long-term volume retention, time to reach steady state, and the effect of postoperative weight changes on these outcomes are not fully understood. [METHODS] I…
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Transcriptome of Capsular Contracture around Breast Implants Mimics Allograft Rejection: A Matched Case-Control Study.
[BACKGROUND] Capsular contracture is a frequent and severe complication following breast implant surgery. Although several theories on the pathophysiology exist, the exact molecular mechanisms remain unclear. This study aimed to identify th…
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Development and Validation of a Diagnostic Histopathological Scoring System for Capsular Contracture Based on 720 Breast Implant Capsules.
[BACKGROUND] Capsular contracture is traditionally evaluated with the Baker classification, but this has notable limitations regarding reproducibility and objectivity. [OBJECTIVES] The aim of this study was to develop and validate procedur…