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Translational and First-in-Human Positron Emission Tomography Targeting Prostatic Acid Phosphatase in Prostate Cancer Using the Ligand [Ga]Ga-OncoACP3-DOTA.
Prostate-specific membrane antigen (PSMA)-targeted theranostic agents have transformed prostate cancer (PC) management, but their performance is limited by variable PSMA expression and off-target uptake. We investigates the first-in-human p…
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[F]TFB PET/CT misses intense [I]iodine-avid metastases after redifferentiation therapy in metastatic thyroid cancer.
[BACKGROUND] Fluorine 18-labelled tetrafluoroborate ([F]TFB) is a substrate for the sodium/iodide symporter. In thyroid cancer, [F]TFB-PET/CT may be an alternative to iodine imaging to evaluate the extent of disease, eligibility for radioio…
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Effects of transgenic expression of botulinum toxins in Drosophila.
Clostridial neurotoxins (botulinum toxins and tetanus toxin) disrupt neurotransmitter release by cleaving neuronal SNARE proteins. We generated transgenic flies allowing for conditional expression of different botulinum toxins and evaluated…