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A Comparative Analysis of Local and Systemic Immunological Biomarkers in Females With Breast Implants and Capsular Contracture.
[BACKGROUND] The etiology of capsular contracture (CC), the most common complication following breast augmentation, remains unclear. Chronic, fibrotic inflammation resulting in excessive fibrosis has been proposed as a potential mechanism. …
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Increased risk of late-onset, immune-mediated, adverse reactions related to dermal fillers in patients bearing HLA-B*08 and DRB1*03 haplotypes.
Even though manufacturers claim that the dermal fillers are nontoxic and nonimmunogenic, adverse events may occur. Clinically and histologically, most of the late onset adverse events present as an inflammatory response. To assess whether H…
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The Aetiopathogenesis of Late Inflammatory Reactions (LIRs) After Soft Tissue Filler Use: A Systematic Review of the Literature.
[BACKGROUND] Late inflammatory reactions (LIRs) are the most challenging complications after filler use. The immune system plays a prominent role in its etiology, albeit to an unknown extent. Bacterial contamination in situ has been hypothe…
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Capsular Contracture in Breast Implant Surgery: Where Are We Now and Where Are We Going?
Capsular contracture is the leading complication after surgery with breast implants. A lot of progress has been made investigating this complication over the years, and knowledge has been gained on this complication. Currently, the exact ca…
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Toll-Like Receptors (TLRs) Expression in Contracted Capsules Compared to Uncontracted Capsules.
[INTRODUCTION] The etiology of capsular contracture after surgical implantation of breast implants remains unclear, but an important role is seen for the immune system. Toll-like receptors are immune receptors recognizing both pathogen-asso…
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PCR Characterization of Microbiota on Contracted and Non-Contracted Breast Capsules.
[BACKGROUND] The aetiology of capsular contracture around breast implants remains unclear. The leading theory is that a subclinical infection around the implant plays a role in the development of capsular contractions. Several studies found…
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Poly Implant Prothèse silicone breast implants: implant dynamics and capsular contracture.
[BACKGROUND] The Poly Implant Prothèse (PIP) implants were withdrawn from the market in 2010 due to the use of low-grade silicone, causing a high risk for implant rupture. The aim of this study was to investigate the implant dynamics of PIP…
- Risk factors for developing capsular contracture in women after breast implant surgery: A systematic review of the literature.
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The aetiopathogenesis of capsular contracture: A systematic review of the literature.
[BACKGROUND] Capsular contracture is the most frequent complication after breast augmentation or reconstruction with breast implants. The immune system plays a prominent role in capsular contracture formation, albeit to an unknown extent. B…
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The Influence of Radiotherapy on the Mechanical Properties of Silicone Breast Implants.
[BACKGROUND] Silicone breast implants have been used for decades for cosmetic breast augmentation or reconstruction after mastectomy. In selected cases, postmastectomy adjuvant radiotherapy is given with the breast implants in situ. Previou…
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Risk factors for developing capsular contracture in women after breast implant surgery: A systematic review of the literature.
[BACKGROUND] Capsular contracture is the most frequent complication in breast augmentation or reconstruction with breast implants. The exact mechanism for this complication is not completely understood. Yet, it is most likely to be a multif…