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Sustained-release of 4-hydroxytamoxifen inhibits capsular contracture after breast implant placement in a mouse model.
[BACKGROUND] Capsular contracture is a major complication of breast reconstruction with silicone implants, affecting patients' quality of life due to pain and esthetic concerns. Capsular contracture is considered to result from an excessive…
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Beneficial effects of transdermal administration of tamoxifen on capsular contracture after breast implantation in murine models.
[BACKGROUND AND AIM] Capsular contracture is the most common complication with smooth-type silicone implants. We investigated the preventive effect of an active metabolite of tamoxifen, 4-hydroxytamoxifen (4-OH TAM), on capsular contracture…