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The molecular basis for immune dysregulation by the hyperactivated E62K mutant of the GTPase RAC2.
The RAS-related C3 botulinum toxin substrate 2 (RAC2) is a member of the RHO subclass of RAS superfamily GTPases required for proper immune function. An activating mutation in a key switch II region of RAC2 (RAC2) involved in recognizing mo…
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Dominant activating RAC2 mutation with lymphopenia, immunodeficiency, and cytoskeletal defects.
Ras-related C3 botulinum toxin substrate 2 (RAC2), through interactions with reduced NAD phosphate oxidase component p67 , activates neutrophil superoxide production, whereas interactions with p21-activated kinase are necessary for fMLF-in…