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Dual-Toxin ("Bivalent") Infant Botulism in California, 1976-2020: Epidemiologic, Clinical, and Laboratory Aspects.
[OBJECTIVE] To assess the consequences of infant botulism that result from Clostridium botulinum strains that produce 2 botulinum toxin serotypes, termed "bivalent." [STUDY DESIGN] Epidemiologic investigations used a standard questionnaire…
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Closed Genome Sequence of Clostridium botulinum Strain IBCA10-7060 Type Bh.
Clostridium botulinum strain IBCA10-7060 was isolated from a stool specimen from an infant botulism patient and is the only Clostridium botulinum strain known that produces botulinum toxin type H. We present here its 4.09-Mbp closed genome …
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Seven-Year Case-Control Study in California of Risk Factors for Infant Botulism.
[OBJECTIVE] To ascertain possible risk factors for infant botulism, the intestinal infectious form of human botulism, in the years immediately following its initial recognition in California in 1976. [STUDY DESIGN] Parents of 159 Californi…
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Descriptive Epidemiology of Infant Botulism in California: The First 40 Years.
[OBJECTIVE] To ascertain the descriptive epidemiology of infant botulism, the flaccid paralysis that results when neurotoxigenic Clostridium species produce botulinum toxin (BoNT) in the infant colon, in its first 40 years following initial…
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Antimicrobial Susceptibility of 260 Clostridium botulinum Type A, B, Ba, and Bf Strains and a Neurotoxigenic Clostridium baratii Type F Strain Isolated from California Infant Botulism Patients.
Infant botulism is an infectious intestinal toxemia that results from colonization of the infant large bowel by (or rarely, by neurotoxigenic or ), with subsequent intraintestinal production and absorption of botulinum neurotoxin that the…
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Immunological Characterization and Neutralizing Ability of Monoclonal Antibodies Directed Against Botulinum Neurotoxin Type H.
[BACKGROUND] Only Clostridium botulinum strain IBCA10-7060 produces the recently described novel botulinum neurotoxin type H (BoNT/H). BoNT/H (N-terminal two-thirds most homologous to BoNT/F and C-terminal one-third most homologous to BoNT/…