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Design and synthesis of pyrazolopyrimidinone derivatives as dual VEGFR/Aurora kinase inhibitors against hepatocellular and breast carcinomas.
Dual inhibition of VEGFR-2 and Aurora A is a promising strategy for treating complex malignancies like hepatocellular carcinoma (HCC) and breast cancer. In this study, a series of new pyrazolopyrimidine derivatives were designed and synthes…