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Loss of anti-proliferative effect of all-trans retinoic acid in advanced stage of breast carcinogenesis.
[BACKGROUND] Mechanisms by which the inhibitory effect of retinoic acid on tumor growth is attenuated as tumors progress to more advanced stages are unclear. [MATERIALS AND METHODS] This study utilizes a novel cell culture system of human …
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Evaluation of sphinganine and sphingosine as human breast cancer chemotherapeutic and chemopreventive agents.
No comparative study of the effects of sphingolipid metabolites on proliferation and differentiation in normal human breast epithelial cells versus stem cells and tumorigenic cells has been reported. The purpose of this study was to evaluat…